One of its chief activities is to create public awareness regarding organ donation especially deceased donation and transplantation. ISOT accepts grants, donations and endowment from the Government, Corporate Houses, public and individuals for achieving the objectives of society and institutes awards, fellowships, scholarships, grants, stipends, remuneration to the students, deserving members and the research scholars to enable them to undertake education, patient care and research in the field of transplantation.

ISOT organizes national, international, regional meetings, conferences, CME and exhibitions. It also interacts with other national and international societies, NGOs, agencies and individuals to promote the objectives of the society. It also interacts with the State and Central Government in formulating laws and policies in the field of transplantation.